FMK | RSK inhibitor | Probechem Biochemicals

Chemical Structure : FMK

CAS No.: 821794-92-7

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FMK (RSK inhibitor FMK)

货号: PC-45920Not For Human Use, Lab Use Only.

FMK is an irreversible inhibitor of the CTD of RSK1 and RSK2 with IC50 of 15 nM for wt RSK2.

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10 mg	￥2980	In stock
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生物&药学活性

FMK is an irreversible inhibitor of the CTD of RSK1 and RSK2 with IC50 of 15 nM for wt RSK2.
FMK shows 600- and 200-fold selectivity over the C436V and T493M mutants, respectively.
FMK inhibits EGF-induced Ser386 phosphorylation of endogenous RSK2 in COS-7 cells (IC50=200 nM).
FMK also potently inhibits a Fyn mutant in which Val285 was replaced with Cys(IC50=100 nM), weakly inhibits WT Fyn with IC50 of 4 uM.

物理化学性质&存储条件

分子量	342.3675
分子式	C18H19FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-

参考文献

1. Cohen MS, et al. Science. 2005 May 27;308(5726):1318-21.

2. Cohen MS, et al. Nat Chem Biol. 2007 Mar;3(3):156-60. Epub 2007 Jan 28.

3. Kang S, et al. Cancer Cell. 2007 Sep;12(3):201-14.

FMK (RSK inhibitor FMK)

生物&药学活性

物理化学性质&存储条件

参考文献

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FMK (RSK inhibitor FMK)

生物&药学活性

物理化学性质&存储条件

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