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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-FM-381
FM-381

Chemical Structure : FM-381

CAS No.: 2226521-65-7

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FM-381 (FM381;FM 381)

货号: PC-63575Not For Human Use, Lab Use Only.

FM-381 (FM381) is a potent, specific, reversible and covalent inhibitor of JAK3 with IC50 of 127 pM, 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and Tyk2, respectively.

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5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥3480 In stock
50 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FM-381 (FM381) is a potent, specific, reversible and covalent inhibitor of JAK3 with IC50 of 127 pM, 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and Tyk2, respectively.
FM-381 targets the unique Cys909 at the gatekeeper position +7 in JAK3.
FM-381 blocks IL2-stimulated (JAK3/JAK1 dependent) STAT5 phosphorylation at 100 nM, but not JAK3 independent IL6-stimulated (JAK1/2/TYK dependent) STAT3 signalling in Human CD4+ T cells.

物理化学性质&存储条件

分子量 428.496
分子式 C24H24N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide

参考文献

1. Forster M, et al. Cell Chem Biol. 2016 Nov 17;23(11):1335-1340.

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