FLTX1 | ER fluorescent | Probechem Biochemicals

Chemical Structure : FLTX1

CAS No.: 1481401-71-1

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FLTX1 (ER fluorescent)

货号: PC-38520Not For Human Use, Lab Use Only.

FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).
FLTX1 exhibits similar affinity for ER than tamoxifen.
FLTX1 exhibited antiestrogenic activity comparable to tamoxifen in MCF7 and T47D cells transfected with 3xERE-luciferase reporter.
FLTX1 lacked the strong agonistic effect of tamoxifen on ERα-dependent transcriptional activity.
FLTX1 is not only a suitable probe for studies on the molecular pharmacology of tamoxifen, but also a potential therapeutic substitute to tamoxifen.

物理化学性质&存储条件

分子量	520.58
分子式	C31H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]ethyl]-N-methyl-7-nitro-2,1,3-benzoxadiazol-4-amine

参考文献

1. Marrero-Alonso J, et al. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):898-910.

2. Morales A, et al. Methods Mol Biol. 2016;1366:163-173.

FLTX1 (ER fluorescent)

生物&药学活性

物理化学性质&存储条件

参考文献

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FLTX1 (ER fluorescent)

生物&药学活性

物理化学性质&存储条件

参考文献

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