FLT3 inhibitor 7c

Chemical Structure : FLT3 inhibitor 7c

CAS No.: 2088735-51-5

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货号: PC-38742Not For Human Use, Lab Use Only.

FLT3 inhibitor 7c is a novel potent FLT3 inhibitor with IC50 of 207.2, 215.3 and 32.5 nM for FLT3 (WT), FLT3 (D835Y) and FLT3 (ITD), respectively.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

FLT3 inhibitor 7c is a novel potent FLT3 inhibitor with IC50 of 207.2, 215.3 and 32.5 nM for FLT3 (WT), FLT3 (D835Y) and FLT3 (ITD), respectively.
FLT3 inhibitor 7c inhibits Molm-13 and MV4-11 proliferation with IC50 of 95.5 and 61.9 nM, respectively.
FLT3 inhibitor 7c inhibits FLT3 signaling in FLT3-ITD+ Molm-13 and MV4-11 cells in vitro.
FLT3 inhibitor 7c inhibits FLT3-downstream effector STAT5 phosphorylation and total STAT5 protein in Molm-13 and MV4-11 cells.

物理化学性质&存储条件

分子量	254.26
分子式	C15H11FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-Fluorophenyl)-N-phenyl-2-oxazolamine

参考文献

1. Hyo Jeong Kim, et al. Molecules. 2020 Nov 5;25(21):5154.