FLLL32 |CAS:1226895-15-3 Probechem Biochemicals

Chemical Structure : FLLL32

CAS No.: 1226895-15-3

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FLLL32 (JAK2 Inhibitor X, FLLL32)

货号: PC-61668Not For Human Use, Lab Use Only.

FLLL32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

FLLL32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).
FLLL32 induces apoptosis in pancreatic and breast cancer cell lines.
FLLL32 also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells.
FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.

物理化学性质&存储条件

分子量	464.6
分子式	C28H32O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one

参考文献

1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.

2. Bill MA, et al. Mol Cancer. 2010 Jun 25;9:165.

3. Fossey SL, et al. BMC Cancer. 2011 Mar 28;11:112.

FLLL32 (JAK2 Inhibitor X, FLLL32)

生物&药学活性

物理化学性质&存储条件

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FLLL32 (JAK2 Inhibitor X, FLLL32)

生物&药学活性

物理化学性质&存储条件

参考文献

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