FLF-15 | ADAM17 inhibitor | Probechem Biochemicals

Chemical Structure : FLF-15

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FLF-15 (ADAM17 inhibitor)

货号: PC-24822Not For Human Use, Lab Use Only.

FLF-15 is a potent, selective ADAM17 inhibitor with IC50 of 10.43 nM, selectively inhibits its IL-6R cleavage activity, inhibits HCC migration and invasion in vitro and in vivo.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FLF-15 is a potent, selective ADAM17 inhibitor with IC50 of 10.43 nM, selectively inhibits its IL-6R cleavage activity, inhibits HCC migration and invasion in vitro and in vivo.
FLF-15 does not inhibit ADAM17 enzymatic activity.
FLF-15 effective with IC50 values for human HCC cell lines MHCC97H and LM3 nearly 7-fold lower than that for normal human hepatic stellate cell LX-2 (2.13 µM and 2.53 µM vs. 15.32 µM, respectively.
FLF-15 inhibits migration and invasion in HCC cells in vitro.
FLF-15 (25 and 50 mg/kg) suppresses the lung metastasis of liver cancer in mouse model.
FLF-15 selectively suppresses IL-6 trans-signaling pathways leads to inactivation of AKT and ERK.

物理化学性质&存储条件

分子量	404.47
分子式	C22H24N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(3-(2-(dimethylamino)ethyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-1H-benzo[d]imidazol-2-yl)propionamide

参考文献

1. Qing Li, et al. Mol Divers. 2025 Jun 26. doi: 10.1007/s11030-025-11275-7.