FL-411 |CAS:2118944-88-8 Probechem Biochemicals

Chemical Structure : FL-411

CAS No.: 2118944-88-8

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FL-411 (FL411)

货号: PC-62636Not For Human Use, Lab Use Only.

FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells.

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10 mg	￥1780	In stock
25 mg	￥2880	In stock
50 mg	￥4280	In stock
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生物&药学活性

FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells.
FL-411 induces ACD pathways involved in HMGB1, VDAC1/2, and eEF2.
FL-411 displays a therapeutic potential on both breast cancer xenograft mouse and zebrafish models.

物理化学性质&存储条件

分子量	341.429
分子式	C18H19N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-Hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

参考文献

1. Ouyang L, et al. J Med Chem. 2017 Dec 28;60(24):9990-10012.

FL-411 (FL411)

生物&药学活性

物理化学性质&存储条件

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FL-411 (FL411)

生物&药学活性

物理化学性质&存储条件

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