FL-18 | p97 inhibitor | Probechem Biochemicals

Chemical Structure : FL-18

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FL-18 (p97 inhibitor FL-18)

货号: PC-72870Not For Human Use, Lab Use Only.

FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.

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生物&药学活性

FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.
FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.
FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).
FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells.

物理化学性质&存储条件

分子量	375.428
分子式	C22H21N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-ethoxyethoxy)-5-(1H-imidazol-2-yl)phenyl)-3-phenylpropiolamide

参考文献

1. Zi Ye, et al. Acta Pharm Sin B. 2022 Feb;12(2):982-989.

FL-18 (p97 inhibitor FL-18)

生物&药学活性

物理化学性质&存储条件

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FL-18 (p97 inhibitor FL-18)

生物&药学活性

物理化学性质&存储条件

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