FKA-9i

Chemical Structure : FKA-9i

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货号: PC-27293Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FKA-9i is a potent broad-spectrum anticancer agent, directly binds to leucine-rich PPR motif-containing protein (LRPPRC), Y-box binding protein 1 (YBX1), and ribophorin I (RPN1) with 7.387 μM, 26.82 μM, and 16.52 μM, respectively, reducing their interactions and stability.
FKA-9i impedes cancer progression via LRPPRC-YBX1-RPN1 mediated MAPK signaling pathway.
FKA-9i induces cancer cell cycle arrest, apoptosis, and mitochondrial dysfunction characterized by suppressed oxidative phosphorylation (OXPHOS) and accumulated reactive oxygen species (ROS).
FKA-9i exhibits a synergistic enhancement effect when combined with chemotherapeutic drugs, YBX1 and RPN1 inhibitors, as well as drugs targeting the glycolysis pathway.

物理化学性质&存储条件

分子量	660.66
分子式	C30H26F2N2O9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-1-Benzopyran-8-sulfonamide, N-(4-fluorophenyl)-2-[3-[[(4-fluorophenyl)amino]sulfonyl]-4-methoxyphenyl]-3,4-dihydro-5,7-dimethoxy-4-oxo-

参考文献

1. Rui Wu, et al. Bioorg Chem. 2026 Mar:170:109425.

FKA-9i

生物&药学活性

物理化学性质&存储条件

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FKA-9i

生物&药学活性

物理化学性质&存储条件

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