FK-866 |CAS:658084-64-1 Probechem Biochemicals

Chemical Structure : FK-866

CAS No.: 658084-64-1

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FK-866 (Daporinad, APO-866, FK886)

货号: PC-45883Not For Human Use, Lab Use Only.

FK-866 (Daporinad, APO-866) is a potent, highly specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with Ki of 0.4 nM.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

FK-866 (Daporinad, APO-866) is a potent, highly specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with Ki of 0.4 nM.
FK-866 (Daporinad, APO-866) effectively induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells with IC50 of 1 nM.
FK-866 (Daporinad, APO-866) causes gradual NAD+ depletion but does not directly inhibit mitochondrial respiratory activity.
FK-866 (Daporinad, APO-866) demonstrates significant anti-MM activity in a xenograft-murine MM model, associated with down-regulation of ERK1/2 phosphorylation and proteolytic cleavage of LC3 in tumor cells.

物理化学性质&存储条件

分子量	391.506
分子式	C24H29N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, (2E)-

参考文献

1. Hasmann M, et al. Cancer Res. 2003 Nov 1;63(21):7436-42.

2. Muruganandham M, et al. Clin Cancer Res. 2005 May 1;11(9):3503-13.

FK-866 (Daporinad, APO-866, FK886)

生物&药学活性

物理化学性质&存储条件

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FK-866 (Daporinad, APO-866, FK886)

生物&药学活性

物理化学性质&存储条件

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