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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-FIPI
FIPI

Chemical Structure : FIPI

CAS No.: 939055-18-2

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FIPI (5-Fluoro-2-indolyl deschlorohalopemide)

货号: PC-43220Not For Human Use, Lab Use Only.

FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2.
FIPI inhibits both the hydrolytic and transphosphatidylation activities of PLD1 and PLD2, rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency (IC50=0.5 nM), does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis。
FIPI attenuates mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.

物理化学性质&存储条件

分子量 421.4674
分子式 C23H24FN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 14.67 mg/mL
Chemical Name/SMILES

1H-Indole-2-carboxamide, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-

参考文献

1. Su W, et al. Mol Pharmacol. 2009 Mar;75(3):437-46.

2. Faugaret D, et al. Biochem Pharmacol. 2011 Jan 1;81(1):144-56.

3. Secor JD, et al. Int J Toxicol. 2011 Dec;30(6):619-38.

4. Olala LO, et al. Mol Cell Endocrinol. 2013 Feb 5;366(1):31-7.

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