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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-FIIN-3
FIIN-3

Chemical Structure : FIIN-3

CAS No.: 1637735-84-2

FIIN-3 (FIIN 3;FIIN3)

货号: PC-45475Not For Human Use, Lab Use Only.

A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM).

规格 价格 库存 数量
5 mg ¥1760 In stock
10 mg ¥2800 In stock
50 mg ¥9600 In stock
100 mg ¥14800 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM); potently inhibits the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, also inhibits EGFR and EGFR (L858R); inhibits proliferation of the SKOV-3 cells with an EC50 of 499 nM.

物理化学性质&存储条件

分子量 691.6068
分子式 C34H36Cl2N8O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mg/mL

Chemical Name/SMILES

2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-

参考文献

1. Tan L, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.

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