Chemical Structure : FIIN-3
CAS No.: 1637735-84-2
货号: PC-45475Not For Human Use, Lab Use Only.
A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM).
规格 | 价格 | 库存 | 数量 |
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5 mg | ¥1760 | In stock | |
10 mg | ¥2800 | In stock | |
50 mg | ¥9600 | In stock | |
100 mg | ¥14800 | In stock |
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A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM); potently inhibits the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, also inhibits EGFR and EGFR (L858R); inhibits proliferation of the SKOV-3 cells with an EC50 of 499 nM.
分子量 | 691.6068 | |
分子式 | C34H36Cl2N8O4 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
DMSO: 10 mg/mL |
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Chemical Name/SMILES |
2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]- |
1. Tan L, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
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