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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-FHT-2344
FHT-2344

Chemical Structure : FHT-2344

CAS No.: 2468058-90-2

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FHT-2344 (FHT2344)

货号: PC-20343Not For Human Use, Lab Use Only.

FHT-2344 (FHT2344) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 26 and 13 nM respectively, the ATPase component of the BAF complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FHT-2344 (FHT2344) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 26 and 13 nM respectively, the ATPase component of the BAF complex.
    FHT-2344 displays no activity against the closely related ATPase CHD4 (IC50>200 uM).
    FHT-2344 elicits lineage-specific effects on chromatin accessibility in treated cancer cells, causes reduced occupancy of master diseaseassociated transcription factors in 92-1 UM cells.
    FHT-2344 affects the proliferation of many cancer cell types, and elicits rapid effects on UM, hematological cancer, and other cell lines inhibits the master transcription factor, SOX10, and its downstream transcriptional program, impacting cell survival and lineage specification.
    FHT-2344 elicits tumor regression, demonstrating therapeutic utility in UM and perhaps other transcription factor-driven cancers.

    物理化学性质&存储条件

    分子量 528.60
    分子式 C23H24N6O5S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(3-methoxy-1-((4-(3-(1-methyl-1H-pyrazol-3-yl)phenyl)thiazol-2-yl)amino)-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide

    参考文献

    1. Elena Battistello, et al. Mol Cell. 2023 Mar 15;S1097-2765(23)00153-3.

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