FHP01 | DDX3X inhibitor | Probechem Biochemicals

Chemical Structure : FHP01

CAS No.: 1985601-04-4

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FHP01 (BA103, DDX3X helicase inhibitor FHP01)

货号: PC-49243Not For Human Use, Lab Use Only.

FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively).

规格	价格	库存
2 mg	￥1880	In stock
5 mg	￥2980	In stock
10 mg	￥4780	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FHP01 (BA103) is a potent, small molecule inhibitor of DDX3X helicase activity with IC50 of 0.3 uM in in vitro enzyme assays, exhibits very effective antiproliferative and killing activity against different breast cancer cell types (IC50=3.058 and 3.21 μM in MDA MB 468 and MDA MB 231, respectively).
FHP01 does not inhibit the ATPase activity of DDX3X and the helicase activity of DDX1 (IC50>100 uM).
FHP01 also inhibits WNT signaling, a key tumorigenic pathway already correlated to DDX3X functions in breast cancer model cell lines.
FHP01 inhibits ER+/PR+ (IC50 = 12.43 and 10.62 μM in MCF7 and T47D cells, respectively) and HER2+ (IC50 = 13.46 μM in SKBR3) cells, but lower in control MCF10A cells (IC50 = 28.71 μM).
FHP01 (45 mg/kg, i.p. injection) suppresses growth of MDA MB 231 tumor xenografts in nude mice.

物理化学性质&存储条件

分子量	403.409
分子式	C20H20F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-butyl-1H-pyrrol-1-yl)phenyl)-3-(2-(trifluoromethyl)phenyl)urea

参考文献

1. Lisa Gherardini, et al. Cancers (Basel). 2021 Sep 27;13(19):4830.

FHP01 (BA103, DDX3X helicase inhibitor FHP01)

生物&药学活性

物理化学性质&存储条件

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FHP01 (BA103, DDX3X helicase inhibitor FHP01)

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物理化学性质&存储条件

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