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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-FH535
FH535

Chemical Structure : FH535

CAS No.: 108409-83-2

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FH535 (FH 535;FH-535)

货号: PC-44658Not For Human Use, Lab Use Only.

FH535 is a potent, dual PPARγ/δ antagonist that is able to inhibit GRIP1 and β-catenin recruitment, inhibits the Wnt/β-catenin pathway.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1480 In stock
100 mg ￥2280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FH535 is a potent, dual PPARγ/δ antagonist that is able to inhibit GRIP1 and β-catenin recruitment, inhibits the Wnt/β-catenin pathway.
FH535 antagonizes β-catenin/Tcf–mediated transcription and inhibits the Wnt/β-catenin pathway.
FH535 shows antiproliferation effect on transformed colon lung and liver cell lines.

物理化学性质&存储条件

分子量 361.2005
分子式 C13H10Cl2N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-

参考文献

1. Handeli S, et al. Mol Cancer Ther. 2008 Mar;7(3):521-9.

2. Gedaly R, et al. PLoS One. 2014 Jun 18;9(6):e99272.

3. Su H, et al. J Transl Med. 2015 Mar 31;13:104.

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