FGIN-1-27 | TSPO agonist | Probechem Biochemicals

Chemical Structure : FGIN-1-27

CAS No.: 142720-24-9

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FGIN-1-27 (FGIN 1-27)

货号: PC-72081Not For Human Use, Lab Use Only.

FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

FGIN-1-27 (FGIN 1-27) is an anxiolytic compound that acts as a selective agonist at the peripheral benzodiazepine receptor (TSPO) with Ki of 5 nM.
FGIN-1-27 inhibited Th17 cell differentiation, significantly downregulated the expression of RORγt target genes, notably Il17a, Il17f, Il23r, Ltb4r1,Ccr6.
FGIN-1-27 protected mice against EAE, induced amino acid starvation response (AAR).
FGIN-1-27 produced anti-anxiety and anti-panic effects in non-mammalian models.

物理化学性质&存储条件

分子量	436.615
分子式	C28H37FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4-Fluorophenyl)-1H-indol-3-yl)-N,N-dihexylacetamide

参考文献

1. Lima-Maximino MG, et al. Pharmacol Biochem Behav. 2018 Aug;171:66-73.

2. Singh A, et al. Sci Rep. 2020 Feb 28;10(1):3766.

3. Musicki B, et al. J Cell Physiol. 2021 Apr;236(4):3073-3082.

4. Rosenberg N, et al. Exp Clin Endocrinol Diabetes. 2018 Feb;126(2):77-84.

FGIN-1-27 (FGIN 1-27)

生物&药学活性

物理化学性质&存储条件

参考文献

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FGIN-1-27 (FGIN 1-27)

生物&药学活性

物理化学性质&存储条件

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