FGF trap compound 57

Chemical Structure : FGF trap compound 57

加入收藏

货号: PC-22625Not For Human Use, Lab Use Only.

FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity.
FGF trap compound 57 potently inhibits FGFR3 phosphorylation in KMS-11 cells about 74% at 6 uM.
FGF trap compound 57 significantly inhibited the formation of HSPG/FGF2/FGFR1 ternary complexes with a potency higher than NSC12 (Cat#PC-60628).
FGF trap compound 57 is able to hamper FGFR activation in FGFR1-overexpressing CHO cells stimulated with FGF2, significantly inhibits FGFR1 phosphorylation.
FGF trap compound 57 strongly reduced the levels of FGFR phosphorylation in MM cell lines.
FGF trap compound 57 (7.5 mg/kg) strongly reduced the growth of MM tumor xenografts in vivo, exerted a stronger antitumor activity compared to NSC12.
FGF trap compound 57 induces cell death in both newly diagnosed and relapsed/refractory patient-derived MM cells.

物理化学性质&存储条件

分子量	554.46
分子式	C28H21F7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4,4-trifluoro-1-(3-((4-fluorophenoxy)methyl)-4-(6-hydroxynaphthalen-2-yl)phenyl)-3-(trifluoromethyl)butane-1,3-diol

参考文献

1. Taranto S, et al. Pharmacol Res. 2024 Jul 3:107291.