FGFR2/3 inhibitor 29

Chemical Structure : FGFR2/3 inhibitor 29

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货号: PC-49450Not For Human Use, Lab Use Only.

FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.
FGFR2/3 inhibitor 29 displays >40-fold selectivity over FGFR1 and FGFR4.
FGFR2/3 inhibitor 29 potently inhibits FGFR3 V555L and V555M gatekeeper mutants with IC50 of 2.7 nM and 6.1 nM, respectively.

物理化学性质&存储条件

分子量	450.517
分子式	C23H22D3N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(6-(1-isopropyl-1H-pyrazol-4-yl)-5-((tetrahydrofuran-3-yl)oxy)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(methyl-d3)nicotinamide

参考文献

1. Shvartsbart A, et al. J Med Chem. 2022 Nov 10. doi: 10.1021/acs.jmedchem.2c01366.