FGF23 inhibitor 13a | FGF23 inhibitor | Probechem Biochemicals

Chemical Structure : FGF23 inhibitor 13a

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FGF23 inhibitor 13a (FGF23-IN-13a)

货号: PC-72720Not For Human Use, Lab Use Only.

FGF23 inhibitor 13a (FGF23-IN-13a) is a ZINC13407541 analogue with enhanced drug-like properties, inhibits FGF23 with IC50 of 0.14 uM.

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生物&药学活性

FGF23 inhibitor 13a (FGF23-IN-13a) is a ZINC13407541 analogue with enhanced drug-like properties, inhibits FGF23 with IC50 of 0.14 uM.
FGF23 inhibitor 13a exhibits greater effects to increase Npt2a and Npt2c message expression, consistent with higher serum phosphate levels in kidney of Hyp mice.
FGF23 inhibitor 13a demonstrates short- and long-term efficacy in blocking FGF23 end-organ effects in Hyp mice, a human homologue of XLH. FGF23 inhibitor 13a efficiently abrogates aberrant FGF23 signaling, corrects hypophosphatemia and aberrant 1,25(OH)2D levels, and improves both bone and renal gene expression profiles caused by elevated FGF23 levels in Hyp mice.

物理化学性质&存储条件

分子量	237.302
分子式	C16H15NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-((E)-4-methylstyryl)benzaldehyde oxime

参考文献

1. Xiao Z, et al. Mol Pharmacol. 2022 Mar 26:MOLPHARM-AR-2021-000471.

FGF23 inhibitor 13a (FGF23-IN-13a)

生物&药学活性

物理化学性质&存储条件

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FGF23 inhibitor 13a (FGF23-IN-13a)

生物&药学活性

物理化学性质&存储条件

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