Roblitinib (FGF-401) | FGFR4 inhibitor | Probechem Biochemicals

Chemical Structure : FGF-401

CAS No.: 1708971-55-4

加入收藏

FGF-401 (NVP-FGF401;Roblitinib;FGF401)

货号: PC-42406Not For Human Use, Lab Use Only.

FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2380	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.
FGF-401 shows >1,000-fold selectivity against of panel of 65 kinases and in a kinome of 456 kinases.
FGF-401 potently inhibits phospho-FGFR4 in vivo, exhibits anti-tumor activity in s several xenograft animal models.

物理化学性质&存储条件

分子量	506.567
分子式	C25H30N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6 mg/mL (Need Ultrasonic)
Chemical Name/SMILES	1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-

参考文献

1. Diana Graus Porta, et al. Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC, AACR.

2. Patent WO2015059668A1, compound example 83.

FGF-401 (NVP-FGF401;Roblitinib;FGF401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FGF-401 (NVP-FGF401;Roblitinib;FGF401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.