FFAR2 agonist 1 (FFAR2 agonist Cpd1) | FFAR2 agonist | Probechem Biochemicals

Chemical Structure : FFAR2 agonist 1

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FFAR2 agonist 1 (FFA2 agonist Cpd1)

货号: PC-28146Not For Human Use, Lab Use Only.

FFAR2 agonist 1 (FFAR2 agonist Cpd1) is a potent, specific small molecule agonist of FFAR2 (GPR43), induces FFAR2 signaling in nM concentration.

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100 mg		Get quote

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生物&药学活性

FFAR2 agonist 1 (FFAR2 agonist Cpd1) is a potent, specific small molecule agonist of FFAR2 (GPR43), induces FFAR2 signaling in nM concentration.
FFAR2 agonist 1 increases both ILC3 frequency and cell number while colonic ILC2s slightly decreased in frequency but not in number.
FFAR2 agonist 1 selectively increases colonic ILC3 expansion and function similar to the effects observed with acetate and propionate.
FFAR2 agonist 1 counteracts intestinal inflammation in various in vivo models of colitis.
FFAR2 agonist 1 ameliorates experimental autoimmune encephalomyelitis (EAE) when applied in the inductive phase of the disease.

物理化学性质&存储条件

分子量	435.90
分子式	C25H22ClNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,5R)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid

参考文献

1. Patent WO 2011/076732 A1.

2. Chun E, et al. Immunity. 2019 Nov 19;51(5):871-884.e6.

3. Jevtić B, et al. EMBO Mol Med. 2026 Sep 3. doi: 10.1038/s44321-026-00517-2.

FFAR2 agonist 1 (FFA2 agonist Cpd1)

生物&药学活性

物理化学性质&存储条件

参考文献

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FFAR2 agonist 1 (FFA2 agonist Cpd1)

生物&药学活性

物理化学性质&存储条件

参考文献

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