FEN1-IN-C20 |CAS:824983-94-0 Probechem Biochemicals

Chemical Structure : FEN1-IN-C20

CAS No.: 824983-94-0

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FEN1-IN-C20

货号: PC-61813Not For Human Use, Lab Use Only.

FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM。
FEN1-IN-C20 significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin。
FEN1-IN-C20 efficiently suppresses cancer progression in combination with cisplatin in mouse models.

物理化学性质&存储条件

分子量	393.417
分子式	C20H15N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21.

2. He L, et al. Mol Oncol. 2017 Jun;11(6):640-654.

3. He L, et al. EBioMedicine. 2016 Dec;14:32-43.

FEN1-IN-C20

生物&药学活性

物理化学性质&存储条件

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FEN1-IN-C20

生物&药学活性

物理化学性质&存储条件

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