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首页-小分子抑制剂&激动剂-Others-Other Targets-FDW028
FDW028

Chemical Structure : FDW028

CAS No.: 2768426-49-7

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FDW028 (FDW-028, FDW 028)

货号: PC-21002Not For Human Use, Lab Use Only.

FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities.
FDW028 exerts potent anti-tumor activities against CRC with IC50 of 5.95 µM and 23.78 µM in SW480 and HCT-8 cells, respectively, significantly represses the migration of SW480 and HCT-8 cells.
FDW028 promotes defucosylation and consequent CMA lysosomal degradation of B7-H3 through CMA pathway.
FDW028 apparently attenuates the expression of both PD-L1 and PD-L2 in CRC cells.
FDW028 attenuates membrane B7-H3 through driving the binding of HSC70 to B7-H3 and consequent autophagolysosomal degradation of B7-H3.
FDW028 (20 mg/kg once the other day, i.v.) prolongs the survival of mice with CRC pulmonary metastases (CRPM).

物理化学性质&存储条件

分子量 388.48
分子式 C22H24N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((benzylamino)methyl)-2-((4-ethylbenzyl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

参考文献

1. Wang M, et al. Cell Death Dis. 2023 Aug 3;14(8):495.

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