FDI-6 |CAS: 313380-27-7 Probechem Biochemicals

Chemical Structure : FDI-6

CAS No.: 313380-27-7

加入收藏

FDI-6 (FOXM1 inhibitor FDI6;NCGC00099374)

货号: PC-36076Not For Human Use, Lab Use Only.

FDI-6 (FOXM1 inhibitor FDI6, NCGC00099374) is a small molecule inhibitor of FOXM1 with IC50 of 22.5 uM (FOXM1 DNA binding inhibition).

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FDI-6 (FOXM1 inhibitor FDI6, NCGC00099374) is a small molecule inhibitor of FOXM1 with IC50 of 22.5 uM (FOXM1 DNA binding inhibition).
FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional downregulation, inhibits growth of MCF-7 breast cancer cells with GI50 of 18.0 uM.
FDI-6 specifically downregulates FOXM1-activated genes with FOXM1.
FDI-6 also can suppress pancreatic cancer cell proliferation and induces their apoptotic cell death, sensitizes pancreatic cancer cells to Etoposide and Gemcitabine induced apoptosis.

物理化学性质&存储条件

分子量	437.43
分子式	C19H11F4N3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Gormally MV, et al. Nat Commun. 2014 Nov 12;5:5165.

FDI-6 (FOXM1 inhibitor FDI6;NCGC00099374)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

FDI-6 (FOXM1 inhibitor FDI6;NCGC00099374)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.