FD3-32

Chemical Structure : FD3-32

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货号: PC-26474Not For Human Use, Lab Use Only.

FD3-32 is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 0.513 nM (Mpro WT) and 2.18 nM (M49L/E166A mutant).

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生物&药学活性

FD3-32 is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 0.513 nM (Mpro WT) and 2.18 nM (M49L/E166A mutant).
FD3-32 shows remarkable antiviral activity with IC50 of 0.794 nM in vitro antiviral efficacy assay using Vero E6 cells infected with SARS-CoV-2 Omicron BA.5.2 (100 TCID50).
FD3-32 is also potent against SARS-CoV-1 and MERS-CoV Mpro.
FD3-32 is more effective as a monotherapy regimen than Paxlovid in reducing viral loads in vivo and protecting infected male mice from acute lung injury.

物理化学性质&存储条件

分子量	546.02
分子式	C27H30ClF2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-3-((S)-2-(2-chloro-2,2-difluoroacetamido)-3,3-dimethylbutanoyl)-N-(cyano(isoquinolin-4-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

参考文献

1. Luo G, et al. Nat Commun. 2026 Apr 4. doi: 10.1038/s41467-026-71436-6.

FD3-32

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物理化学性质&存储条件

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FD3-32

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物理化学性质&存储条件

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