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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-FCPR03
FCPR03

Chemical Structure : FCPR03

CAS No.: 1917347-65-9

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FCPR03 (FCPR 03)

货号: PC-62973Not For Human Use, Lab Use Only.

FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.

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2 mg ￥1480 In stock
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.
FCPR03 displays >2,000-fold selectivity over other PDEs.
FCPR03 effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo.
FCPR03 displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo.

物理化学性质&存储条件

分子量 299.318
分子式 C15H19F2NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-isopropylbenzamide

参考文献

1. Zou ZQ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77.

2. Zhou ZZ, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):135-146.

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