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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-FC162
FC162

Chemical Structure : FC162

CAS No.: 2101277-26-1

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FC162 (FC 162)

货号: PC-21495Not For Human Use, Lab Use Only.

FC162 is a potent inhibitor of DYRK1A with IC50 of 11, 18, and 68 nM, against DYRK1A, CLK1, and GSK3, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

FC162 is a potent inhibitor of DYRK1A with IC50 of 11, 18, and 68 nM, against DYRK1A, CLK1, and GSK3, respectively.
FC162 (0-30 uM) dose-dependently inhibits Tau phosphorylation at Thr21 in SH-SY5Y cells expressing Tau.
FC162 reduces cyclin D3 phosphorylation and impairs the entry to quiescent state.
FC162 treatment phenocopies the effect of Dyrk1a genetic deletion in pre-B cells.

物理化学性质&存储条件

分子量 320.37
分子式 C17H12N4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-cyclopropyl-2(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one

参考文献

1. Corinne Fruit, et al. Pharmaceuticals (Basel). 2019 Dec 17;12(4):185.

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