Bofutrelvir (FB2001) | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : FB2001

CAS No.: 2103278-86-8

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FB2001 (Bofutrelvir, FB 2001)

货号: PC-21450Not For Human Use, Lab Use Only.

Bofutrelvir (FB2001) is a potent, selective and covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 value of 53 nM.

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10 mg	￥5980	In stock
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生物&药学活性

Bofutrelvir (FB2001) is a potent, selective and covalent SARS-CoV-2 main protease (Mpro) inhibitor with IC50 value of 53 nM.
Bofutrelvir (FB2001) covalently binds to cysteine 145 of Mpro.
Bofutrelvir (FB2001) shows antiviral activity against several current SARS-CoV-2 variants in vitro.
Bofutrelvir (FB2001) potently inhibitsthe replication of SARS-CoV-2 variants (B.1.1.7 (Alpha): EC50=0.39 μM, B.1.351 (Beta): EC50=0.28 μM; B.1.617.2 (Delta): EC50=0.27 μM; B.1.1.529 (Omicron): EC50=0.26 μM) in Vero E6 cells.
Combined treatment with remdesivir and FB2001 exhibits an additive effect against SARS-CoV-2 in vitro.
Bofutrelvir (FB2001) (100 mpk) exhibits in vivo inhibitory activity of FB2001 in K18-hACE2 mice model of SARS-CoV-2 delta variant infection.

物理化学性质&存储条件

分子量	452.56
分子式	C25H32N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-1H-indole-2-carboxamide

参考文献

1. Shang W, et al. Antiviral Res. 2022 Dec;208:105450.

FB2001 (Bofutrelvir, FB 2001)

生物&药学活性

物理化学性质&存储条件

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FB2001 (Bofutrelvir, FB 2001)

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物理化学性质&存储条件

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