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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-FAUC 1036
FAUC 1036

Chemical Structure : FAUC 1036

CAS No.: 1869983-83-4

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FAUC 1036 (FAUC1036, FAUC-1036)

货号: PC-61170Not For Human Use, Lab Use Only.

FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.

    物理化学性质&存储条件

    分子量 744.933
    分子式 C45H52N4O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tert-Butyl {(S)-1-[(2,2-diphenylethyl)amino]-1-oxo-6-[(S)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido]hexan-2-yl}carbamate

    参考文献

    1. Milanos L, et al. J Med Chem. 2016 Mar 10;59(5):2222-43.

    2. Milanos L, et al. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15277-15281.

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