FASstatin | FASN inhibitor | Probechem Biochemicals

Chemical Structure : FASstatin

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FASstatin (FASNi-8)

货号: PC-21673Not For Human Use, Lab Use Only.

FASstatin (FASNi-8) is an orally bioavailable small-molecule inhibitor of fatty acid synthase (FASN), directly binds FASN with SPR KD of 16 uM, potentiates TRIM56-mediated FASN ubiquitination.

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生物&药学活性

FASstatin (FASNi-8) is an orally bioavailable small-molecule inhibitor of fatty acid synthase (FASN), directly binds FASN with SPR KD of 16 uM, potentiates TRIM56-mediated FASN ubiquitination.
FASstatin has higher suppressive effects on FASN protein expression, comparable FASN enzyme inhibition (FAS inhibitor C75), and higher efficacy insuppressing lipid droplet formation.
TRIM56 directly interacts with FASN and triggers its K48-linked ubiquitination-dependent degradation, FASstatin promotes TRIM56 dependent FASN ubiquitination.
FASstatin (50 mg/kg, p.o.) improved NAFLD and NASH pathologies in mice, did not affect body weight and the weight of liver, kidney, heart, lung and spleen.

物理化学性质&存储条件

分子量	534.64
分子式	C32H31FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-fluorophenyl)(4-(3-methyl-6-(4-methylbenzyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-1,4-diazepan-1-yl)methanone

参考文献

1. Suowen Xu, et al. J Clin Invest. 2024 Jan 11:e166149.

FASstatin (FASNi-8)

生物&药学活性

物理化学性质&存储条件

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FASstatin (FASNi-8)

生物&药学活性

物理化学性质&存储条件

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