FAS inhibitor C75 |CAS:218137-86-1 Probechem Biochemicals

Chemical Structure : FASN inhibitor C75

CAS No.: 218137-86-1

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FASN inhibitor C75 (C75; FAS inhibitor C75)

货号: PC-43005Not For Human Use, Lab Use Only.

FASN inhibitor C75 is a synthetic, slow-binding inhibitor of mammalian fatty acid synthesis (FASN, FAS), binds to and inhibits mammalian FAS and inhibits fatty acid synthesis in human cancer cells (SKBR3 cells ID50=5.0 ug/mL).

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FASN inhibitor C75 is a synthetic, slow-binding inhibitor of mammalian fatty acid synthesis (FASN, FAS), binds to and inhibits mammalian FAS and inhibits fatty acid synthesis in human cancer cells (SKBR3 cells ID50=5.0 ug/mL).
FASN inhibitor C75 causes changes in peripheral tissues, including inhibition of hepatic fatty acid synthesis, reduction of fatty liver, diminished adipose tissue mass, and high levels of malonyl-CoA.
FASN inhibitor C75 reduces food consumption and increases both fatty acid oxidation and energy expenditure in DIO mice.
FASN inhibitor C75 also sensitizes the efficacy of radiotherapy of prostate carcinoma.

物理化学性质&存储条件

分子量	254.3221
分子式	C14H22O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-

参考文献

1. Kuhajda FP, et al. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3450-4.

2. Gao S, et al. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

3. Thupari JN, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

4. Rae C, et al. Radiat Res. 2015 Nov;184(5):482-93.

FASN inhibitor C75 (C75; FAS inhibitor C75)

生物&药学活性

物理化学性质&存储条件

参考文献

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FASN inhibitor C75 (C75; FAS inhibitor C75)

生物&药学活性

物理化学性质&存储条件

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