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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Focal Adhesion Kinase (FAK)-FAK inhibitor E2
FAK inhibitor E2

Chemical Structure : FAK inhibitor E2

CAS No.: 2890814-94-3

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FAK inhibitor E2

货号: PC-22876Not For Human Use, Lab Use Only.

FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth.

物理化学性质&存储条件

分子量 567.69
分子式 C32H37N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl) piperidin-1-yl) phenyl) amino)-7H-pyrrolo[2,3-d] pyrimidin-4-yl) oxy)-2,3-dihydro-1H-inden-1-one

参考文献

1. Zhanzhan Feng, et al. Biochem Pharmacol. 2024 Aug 3:116461.

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