FABP4/5 inhibitor compound 3

Chemical Structure : FABP4/5 inhibitor compound 3

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货号: PC-38573Not For Human Use, Lab Use Only.

FABP4/5 inhibitor compound 3 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.02 and 0.56 uM, respectively.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

FABP4/5 inhibitor compound 3 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.02 and 0.56 uM, respectively.
FABP4/5 inhibitor compound 3 inhibited basal or isoproterenol-stimulated lipolysis in 3T3-L1 and primary human adipocytes.
FABP4/5 inhibitor compound 3 inhibited basal and LPS-stimulated MCP-1 release from THP-1 cells and primary human macrophages.
FABP4/5 inhibitor compound 3 ameliorated dyslipidemia but not insulin resistance in DIO mice.

物理化学性质&存储条件

分子量	427.285
分子式	C21H16Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-5-((3-chloro-2-cyclopropylphenoxy)methyl)-2-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one

参考文献

1. Hong Lan, et al. J Lipid Res. 2011 Apr;52(4):646-56.