FABP1 inhibitor 44

Chemical Structure : FABP1 inhibitor 44

加入收藏

货号: PC-22077Not For Human Use, Lab Use Only.

FABP1 inhibitor 44 is a highly selective, first-in-class FABP1 inhibitor with IC50 of 4.46 uM, does not inhibit other subtypes of FABP (FABP3/4).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

FABP1 inhibitor 44 is a highly selective, first-in-class FABP1 inhibitor with IC50 of 4.46 uM, does not inhibit other subtypes of FABP (FABP3/4).
FABP1 inhibitor 44 (20 mg/kg, p.o. once a day) relieved histological characteristics in NASH mice, has comparable therapeutic efficacy with OCA.
FABP1 inhibitor 44 reduces the liver total triglyceride (TG), total cholesterol (TC), and serum TC levels in NASH mouse model co-induced by WD and CCl4.
FABP1 inhibitor 44 attenuates hepatic fibrosis in the NASH model, exhibits hepatoprotection and against oxidative stress in the liver.

物理化学性质&存储条件

分子量	479.53
分子式	C30H25NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3'-(cyclopropylmethoxy)-5-(3-phenoxybenzamido)-[1,1'-biphenyl]-3-carboxylic acid

参考文献

1. Ya Chen, et al. Eur J Med Chem. 2024 Mar 29:270:116358.