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首页-小分子抑制剂&激动剂-Others-Other Targets-F83236
F83236

Chemical Structure : F83236

CAS No.:

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F83236 (F 83236)

货号: PC-20735Not For Human Use, Lab Use Only.

F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.
F83236 has potent and specific inhibitory activity against CypA, CypB, and CypD.
F83236 prevents mPTP opening in mitochondria from primary human and mouse hepatocytes and protected mice from liver ischemia-reperfusion injury upon binding catalytic and gatekeeper pockets of CypD.

物理化学性质&存储条件

分子量 633.61
分子式 C32H33BrN4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NCC1=CC2=C(NCCC2)C=C1)NC(C3=CC(Br)=CC=C3OC)C(N4C(C5=C6C(C=CS6)=CC=C5)CCC4)=O

参考文献

1. Jens Van Bael, et al. Int J Mol Sci. 2023 Apr 12;24(8):7163.

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