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首页-小分子抑制剂&激动剂-Others-Other Targets-F759
F759

Chemical Structure : F759

CAS No.: 2649904-85-6

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F759 (F 759)

货号: PC-20736Not For Human Use, Lab Use Only.

F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets.
F759 has potent and specific inhibitory activity against CypA, CypB, and CypD.
F759 prevents mPTP opening in mitochondria from primary human and mouse hepatocytes and protected mice from liver ischemia-reperfusion injury upon binding catalytic and gatekeeper pockets of CypD.

物理化学性质&存储条件

分子量 474.62
分子式 C27H30N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC(C1=CC=CC=C1)C(N2C(C3=CC=CC=C3SC)CCC2)=O)NCC4=CC=C(N)C=C4

参考文献

1. Jens Van Bael, et al. Int J Mol Sci. 2023 Apr 12;24(8):7163.

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