F5446 | SUV39H1 inhibitor | Probechem Biochemicals

Chemical Structure : F5446

CAS No.: 2304465-89-0

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F5446 (F 5446, F-5446)

货号: PC-72045Not For Human Use, Lab Use Only.

F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay.

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5 mg	￥2580	In stock
10 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay.
F5446 treatment reduced H3K9me3 in the promoter regions of Gzmb, Prf1, Faslg, and Ifng in activated T cells, significantly increased the percentage of granzyme B-, IFNγ-, and FasL-positive T cells, increased the protein levels (MFI) of granzyme B, IFNγ, and FasL.
F5446 increased T-cell effector gene expression to suppress colon carcinoma growth in vivo.

物理化学性质&存储条件

分子量	552.938
分子式	C26H17ClN2O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(2-Furanyl)-5-[(tetrahydro-2H-pyran-4-yl)carbonyl]-2-thiazolyl]-6-methyl-3-pyridinecarboxamide

参考文献

1. Lu C, et al. Cancer Immunol Res. 2019 Mar;7(3):414-427.

2. Lu C, et al. Cancer Lett. 2020 Apr 28;476:87-96.

F5446 (F 5446, F-5446)

生物&药学活性

物理化学性质&存储条件

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F5446 (F 5446, F-5446)

生物&药学活性

物理化学性质&存储条件

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