F389-0736

Chemical Structure : F389-0736

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货号: PC-28611Not For Human Use, Lab Use Only.

F389-0736 is a potent, selective and effective MAP4K4 inhibitor with IC50 of 44 nM.

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生物&药学活性

F389-0736 is a potent, selective and effective MAP4K4 inhibitor with IC50 of 44 nM.
F389-0736 shows negligible inhibition of MAP4K1, PAK4, and STK24, with limited off-target kinase inhibition across the tested panel.
F389-0736 engages MAP4K4 and suppresses downstream signalling in pancreatic cancer cells.
F389-0736 suppresses TAK1, JNK, and p38 phosphorylation and significantly reduces cell viability and proliferation, with IC50 and GI50 values of 4.41-4.65 μM and 4.03-5.12 μM, respectively.
F389-0736 induces Sub-G1 accumulation and apoptotic signalling.
F389-0736 induces tumour-cell-intrinsic inflammatory activation, suppresses tumour-associated gene programs, perturbs survival and metabolic signalling, and enriches multiple programmed cell death-associated pathways.

物理化学性质&存储条件

分子量	454.96
分子式	C24H27ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(3-chlorobenzylidene)-N-(2-(4-ethylpiperazin-1-yl)ethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxamide

参考文献

1. Yi-Wen Wu, et al. J Enzyme Inhib Med Chem. 2026 Dec;41(1):2743434.

F389-0736

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物理化学性质&存储条件

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F389-0736

生物&药学活性

物理化学性质&存储条件

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