F3406 |CAS:1115899-15-4 Probechem Biochemicals

Chemical Structure : F3406

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F3406 (F-3406;VU0621623;F3406-2010)

货号: PC-60495Not For Human Use, Lab Use Only.

F3406 (VU0621623, F3406-2010) is a novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity.

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生物&药学活性

F3406 (VU0621623, F3406-2010) is a novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity.
F3406 inhibits LCMV cell entry by specifically interfering with the pH-dependent fusion in the endosome compartment that is mediated by LCMV glycoprotein GP2.
F3406 inhibits LCMV multiplication with IC50 of 0.4, 0.7 and 0.9 uM in A549 BHK-21 and Vero cells, respectively.

物理化学性质&存储条件

分子量	449.477
分子式	C20H21F2N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-difluorophenyl)-2-(5,7-dioxo-6-propyl-2-(pyrrolidin-1-yl)-6,7-dihydrothiazolo[4,5-d]pyrimidin-4(5H)-yl)acetamide

参考文献

1. Ngo N, et al. J Virol. 2015 Nov;89(21):10924-33.

F3406 (F-3406;VU0621623;F3406-2010)

生物&药学活性

物理化学性质&存储条件

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F3406 (F-3406;VU0621623;F3406-2010)

生物&药学活性

物理化学性质&存储条件

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