F0045(S) | Influenza HA inhibitor | Probechem Biochemicals

Chemical Structure : F0045(S)

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F0045(S) (F0045 S enantiomer)

货号: PC-38258Not For Human Use, Lab Use Only.

F0045(S) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.

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生物&药学活性

F0045(S) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.
Compound F0045 binds to pockets in the HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.
F0045(S) exhibited in vitro neutralization activity against multiple H1N1 and H5N1 strains.
F0045(S) readily neutralized MDCK-SIAT1 infection by H1/Beijing (EC50=1.6 μM), H1/Cal04 (EC50 =3.9 μM), and H5 A/Vietnam/1203/2004 (EC50 =22.8 μM).

物理化学性质&存储条件

分子量	336.212
分子式	C17H15Cl2NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(2,4-dichlorophenyl)(2-phenylmorpholino)methanone

参考文献

1. Yao Yao, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438.

F0045(S) (F0045 S enantiomer)

生物&药学活性

物理化学性质&存储条件

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F0045(S) (F0045 S enantiomer)

生物&药学活性

物理化学性质&存储条件

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