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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-Ezeprogind free base
Ezeprogind free base

Chemical Structure : Ezeprogind free base

CAS No.: 615539-20-3

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Ezeprogind free base (AZP2006)

货号: PC-38100Not For Human Use, Lab Use Only.

Ezeprogind (AZP2006) is a lysotropic molecule with neuroprotective effects, binds to PGRN/PSAP complex with higher affinity (Kd=201 nM) than PSAP (Kd=624 nM), inhibits TLR9 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ezeprogind (AZP2006) is a lysotropic molecule with neuroprotective effects, binds to PGRN/PSAP complex with higher affinity (Kd=201 nM) than PSAP (Kd=624 nM), inhibits TLR9 receptors.
AZP2006 prevents neuronal death induced by Aβ injury, and reduces the associated microglial activation in rat cortical neurons.
AZP2006 prevent Aβ25-35 damages in AD mice model.
AZP2006 significantly improved senescence behavior and markers in SAMP8 mice.

物理化学性质&存储条件

分子量 428.669
分子式 C25H44N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(4-(3-(Diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine

参考文献

1. N Callizot, et al. Sci Rep. 2021 Aug 19;11(1):16806.

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