Chemical Structure : Extracellular vesicle enhancer 634
CAS No.:
882291-37-4
Extracellular vesicle enhancer 634
(Compound 634)
货号: PC-20657Not For Human Use, Lab Use Only.
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
大包装，大折扣！
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
Compound 634 induced Ca2+ influx in primary mBMDCs, and the increase of intracellular Ca2+ was comparable to that of ION (1 μM).
Compound 634 (10 uM) enhanced EV release in mBMDCs.
Compound 634 enhanced costimulatory molecule expression on mBMDC, 634-treated mBMDCs also had increased CD86 and CD80 expression.
Compound 634 is a Ca2+ influx inducer mediated by SOCE, EVs isolated from 634-treated mBMDCs induced T cell proliferation in the presence of antigenic peptides.
物理化学性质&存储条件
|
分子量
|
397.48
|
|
分子式
|
C15H15N3O4S3
|
|
外观性状
|
Solid
|
|
CAS No.
|
|
|
储存条件
|
- 固体粉末
-
-20°C 12 个月; 4°C 6 个月
|
- 配置液
-
-80°C 6 个月; -20°C 6 个月
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)SC(C)=C1C)OCC
|
参考文献
1. Sako Y, et al. ACS Chem Biol. 2023 Apr 11. doi: 10.1021/acschembio.3c00134.
