Exifone | HDAC1 activator | Probechem Biochemicals

Chemical Structure : Exifone

CAS No.: 52479-85-3

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Exifone (Adlone)

货号: PC-25163Not For Human Use, Lab Use Only.

Exifone is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM.

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25 mg	￥1480	In stock
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生物&药学活性

Exifone is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM.
Exifone treatment of human induced pluripotent stem cell (iPSC)-derived neuronal cells leads to a measurable decrease in histone acetylation.
Exifone treatment can provide neuroprotection in the context of human neurons derived from patient with tauopathy.
Exifone is able to reduce DNA damage in vivo in an AD mouse model.

物理化学性质&存储条件

分子量	278.22
分子式	C13H10O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,3',4,4',5'-hexahydroxybenzophenone

参考文献

1. Patnaik D, et al. ACS Chem Neurosci. 2021 Jan 20;12(2):271-284.

Exifone (Adlone)

生物&药学活性

物理化学性质&存储条件

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Exifone (Adlone)

生物&药学活性

物理化学性质&存储条件

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