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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Glucocorticoid receptor (GR)-Exicorilant
Exicorilant

Chemical Structure : Exicorilant

CAS No.: 1781244-77-6

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Exicorilant (CORT125281;CORT-125281)

货号: PC-35449Not For Human Use, Lab Use Only.

Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist, exhibits no cross-reactivity for the PR and AR receptors..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist, exhibits no cross-reactivity for the PR and AR receptors.

    物理化学性质&存储条件

    分子量 589.57
    分子式 C26H23F4N7O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyl-2H-1,2,3-triazole-4-sulfonyl)-1,4,5,6,7,8,8a,9-octahydro-4aHpyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin2-yl]methanone

    参考文献

    1. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421.

    2. Kroon J, et al. Endocrinology. 2018 Jan 1;159(1):535-546.

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