Exenatide (Exendin-4)

Chemical Structure : Exenatide

CAS No.: 141758-74-9

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货号: PC-43538Not For Human Use, Lab Use Only.

Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

Exenatide (Exendin-4) is a 39-aa peptide, highly potent, long-acting glucagon-like peptide-1 receptor (GLP-1) agonist with IC50 of 3.22 nM.
Exenatide (Exendin-4) significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner in human umbilical vein endothelial cells.
Exenatide (Exendin-4) exhibits cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 uM。
Exenatide (Exendin-4) reduces serum glucose, insulin levels and calculated HOMA in ob/ob mice.

物理化学性质&存储条件

分子量	4186.572
分子式	C184H282N50O60S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL; H2O: 1.23 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	L-Serinamide, L-histidylglycyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isole

参考文献

1. Eng J, et al. J Biol Chem. 1992 Apr 15;267(11):7402-5.

2. Fidan-Yaylalı G, et al. Tumour Biol. 2016 Feb;37(2):2647-53.

3. Schepp W, et al. Eur J Pharmacol. 1994 Oct 14;269(2):183-91.

4. Doyle ME, et al. Regul Pept. 2003 Jul 15;114(2-3):153-8.