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首页-抗体药物偶连体和PROTACs-ADC Cytotoxin-Exatecan
Exatecan

Chemical Structure : Exatecan

CAS No.: 171335-80-1

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Exatecan (DX-8951, DX8951)

货号: PC-28464Not For Human Use, Lab Use Only.

Exatecan (DX-8951) is a potent DNA topoisomerase I (Topo I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL), exerts its cytotoxic effect by trapping the TOP1-DNA cleavage complex (TOP1cc), is a cytotoxic payload for ADCs.

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100 mg ￥580 In stock
250 mg ￥880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Exatecan (DX-8951) is a potent DNA topoisomerase I (Topo I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL), exerts its cytotoxic effect by trapping the TOP1-DNA cleavage complex (TOP1cc), is a cytotoxic payload for ADCs.

物理化学性质&存储条件

分子量 435.46
分子式 C24H22FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione

参考文献

1. Mitsui I, et al. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

2. Sun FX, et al. Cancer Res. 2003 Jan 1;63(1):80-5.

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