Evybactin

Chemical Structure : Evybactin

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货号: PC-23656Not For Human Use, Lab Use Only.

Evybactin is a potent and selective antibiotic acting against M. tuberculosis (MIC=0.25 ug/mL) targeting DNA gyrase.

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生物&药学活性

Evybactin is a potent and selective antibiotic acting against M. tuberculosis (MIC=0.25 ug/mL) targeting DNA gyrase.
Evybactin show no activity against a panel of commensal bacteria, including Lactobacillus sp. and Bacteroides sp., and no toxicity against HepG2, FaDu and HEK293 human cells.
A single dose of 25 mg/kg of Evybactin showed significant efficacy, and a 100 mg/kg dose of Evybactin completely protected mice from E. coli infection.
Evybactin is a general poison of bacterial type IIA topoisomerases, with a preference for gyrase as compared to topo IV.

物理化学性质&存储条件

分子量	1488.54
分子式	C64H89N21O21
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,7S,10R,16S,19R,23S,26S,29S,30R)-16-benzyl-29-[[(2R)-5-carbamimidamido-2-[[(2S,3R)-2-[[(2S)-2-formamido-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]-10-(3-carbamimidamidopropyl)-7,19-bis(hydroxymethyl)-30-methyl-26-[(3-methylimidazol-4-yl)methyl]-2,6,9,12,15,18,21,25,28-nonaoxo-1-oxa-5,8,11,14,17,20,24,27-octazacyclotriacontane-4,23-dicarboxylic acid

参考文献

1. Imai Y, et al. Nat Chem Biol. 2022 Nov;18(11):1236-1244.

Evybactin

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Evybactin

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