Evogliptin |CAS:1222102-29-5 Probechem Biochemicals

Chemical Structure : Evogliptin

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Evogliptin (DA-1229;DA1229)

货号: PC-61445Not For Human Use, Lab Use Only.

Evogliptin (DA1229) is a potent, long acting, reversible and competitive DPP-4 inhibitor with IC50 of 0.9 nM.

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生物&药学活性

Evogliptin (DA1229) is a potent, long acting, reversible and competitive DPP-4 inhibitor with IC50 of 0.9 nM.
Evogliptin (DA1229) displays >600-fold selectivity over DPP8 and DPP9.
Evogliptin (DA1229) increases levels of plasma GLP-1 and insulin, and lowers blood glucose levels in mice (0.1-3 mg/kg).

物理化学性质&存储条件

分子量	401.43
分子式	C19H26F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one

参考文献

1. Kim MK, et al. Life Sci. 2012 Jan 2;90(1-2):21-9.

2. Kim HJ, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3809-12.

3. Kim TH, et al. Eur J Pharmacol. 2016 Jan 15;771:65-76.

4. Chae YN, et al. PLoS One. 2015 Dec 3;10(12):e0144064.

Evogliptin (DA-1229;DA1229)

生物&药学活性

物理化学性质&存储条件

参考文献

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Evogliptin (DA-1229;DA1229)

生物&药学活性

物理化学性质&存储条件

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