Evobrutinib |CAS:1415823-73-2 Probechem Biochemicals

Chemical Structure : Evobrutinib

CAS No.: 1415823-73-2

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货号: PC-42336Not For Human Use, Lab Use Only.

Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.

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Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.

Evobrutinib shows IC50 of 61 nM in the human peripheral blood mononuclear cell (PBMC) assay.

Evobrutinib shows high selectivity for BTK over epidermal growth factor receptor and other Tec family kinases.

Evobrutinib shows potential in several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

分子量	429.51418
分子式	C25H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.4 mg/mL (Need ultrasonic)
Chemical Name/SMILES	2-Propen-1-one, 1-[4-[[[6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino]methyl]-1-piperidinyl]-

1. Patent US20140162983 example 0174.
2. Caldwell RD, et al. J Med Chem. 2019 Sep 12;62(17):7643-7655.