Etoricoxib | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : Etoricoxib

CAS No.: 202409-33-4

加入收藏

Etoricoxib (MK-0663, MK0663)

货号: PC-20873Not For Human Use, Lab Use Only.

Etoricoxib (MK-0663) is a potent, selective and orally active inhibitor of COX-2 with IC50 of 1.1 uM for COX-2 (LPS-induced prostaglandin E2 synthesis), shows no activity against COX-1.

规格	价格	库存
100 mg	￥1980	In stock
200 mg	￥2980	In stock
1 g		Get quote
5 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Etoricoxib (MK-0663) is a potent, selective and orally active inhibitor of COX-2 with IC50 of 1.1 uM for COX-2 (LPS-induced prostaglandin E2 synthesis), shows no activity against COX-1.
Etoricoxib does not inhibit platelet or human recombinant COX-1 under most assay conditions (IC50>100 uM).
Etoricoxib is a potent inhibitor in models of carrageenan-induced paw edema (ID(50) 0.64 mg/kg), carrageenan-induced paw hyperalgesia (ID(50)=0.34 mg/kg), LPS-induced pyresis (ID(50) = 0.88 mg/kg), and adjuvant-induced arthritis (ID(50)=0.6 mg/kg/day) in rats.
Etoricoxib reversed LPS-induced pyresis by 81% within 2 h of administration at a dose of 3 mg/kg and showed no effect in a fecal 51Cr excretion model of gastropathy at 100 mg/kg/day for 5 days.

物理化学性质&存储条件

分子量	358.84
分子式	C18H15ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine

参考文献

1. Riendeau D, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):558-66.

2. Chauret N, et al. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62.

Etoricoxib (MK-0663, MK0663)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Etoricoxib (MK-0663, MK0663)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.